Product Usage: This product is intended for research purposes only.
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PEG MGF 2mg
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
PEG-MGF (Pegylated Mechano Growth Factor) is a PEGylated derivative of mechano growth factor (MGF), an alternatively spliced isoform of the IGF-1 gene. PEGylation substantially alters the compound's pharmacokinetic profile by increasing molecular size and reducing clearance, enabling prolonged exposure relative to native MGF. Experimental investigations have examined PEG-MGF's interactions with IGF-1-associated signaling pathways, including PI3K/Akt, MAPK/ERK, and other regulatory networks involved in cellular growth and differentiation processes. Research has explored its role in satellite cell-associated signaling, myogenic pathway regulation, growth factor-mediated signal transduction, and comparative investigations of IGF-1 splice variants. These characteristics make PEG-MGF a valuable research tool for studies of myogenesis-associated pathways, IGF-1 isoform pharmacology, growth factor signaling mechanisms, and cellular differentiation processes.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
| Chemical Formula | C121H200N42O39 |
|---|---|
| Synonyms | Pegylated Mechano Growth Factor, PEG-MGF, PEG IGF-1 Ec |
| Molar Mass | 2,867.14 g/mol |
| CAS Number | 108174-48-7 |
| PubChem CID | N/A |
| Total Compound Content | 2 mg per vial |
| Shelf Life | 36 months |
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
What is the mechanistic difference between PEG-MGF and IGF-1 LR3 in research models?
PEG-MGF and IGF-1 LR3 are both derived from the IGF-1 signaling system but are investigated for distinct aspects of growth factor biology. IGF-1 LR3 is primarily utilized in studies of IGF-1 receptor-mediated signaling pathways, including PI3K/Akt and MAPK/ERK regulatory networks. PEG-MGF, derived from the MGF splice variant of IGF-1, is frequently investigated in studies of satellite cell-associated signaling, cellular proliferation mechanisms, myogenic pathway regulation, and growth factor-mediated cellular responses. Together, they provide complementary tools for examining different dimensions of IGF-1-associated signaling biology.
Why is PEGylation used in PEG-MGF research?
PEGylation involves covalent attachment of polyethylene glycol chains to a peptide structure, increasing molecular size and reducing susceptibility to enzymatic degradation. This modification substantially extends biological persistence relative to native MGF while preserving the compound's utility as a research tool. PEGylation is widely employed in peptide pharmacology to improve stability, alter pharmacokinetic properties, and enable investigation of signaling pathways over extended experimental timeframes.
What role does PEG-MGF play in satellite cell and myogenesis research?
PEG-MGF is widely utilized in studies of satellite cell-associated signaling pathways, cellular proliferation mechanisms, growth factor-mediated regulation, and myogenic biology. Experimental investigations have examined its interactions with signaling networks involved in cellular differentiation, tissue remodeling processes, and growth factor-regulated molecular pathways. These characteristics make PEG-MGF a valuable research tool for mechanistic studies of satellite cell biology, myogenesis-associated signaling, and IGF-1 splice variant pharmacology.
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