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5-Amino-1MQ (50mg/capsule), 60 Capsules
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
5-Amino-1MQ (5-Amino-1-methylquinolinium iodide) is a selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in nicotinamide methylation and cellular methyl-donor utilization pathways. By inhibiting NNMT activity, 5-Amino-1MQ modulates enzymatic processes associated with nicotinamide metabolism, methylation network regulation, and intracellular cofactor-associated signaling systems. Experimental investigations have examined the relationship between NNMT inhibition and regulatory pathways involving nicotinamide turnover, methylation dynamics, transcriptional control mechanisms, and downstream signal transduction processes.
Its well-characterized pharmacological profile has established 5-Amino-1MQ as a valuable research tool for studying NNMT enzyme biology, enzyme-inhibitor interactions, methylation pathway regulation, nicotinamide-associated metabolic networks, and structure-activity relationships involving NNMT-targeting compounds. Research applications include NNMT pharmacology, methyltransferase signaling studies, enzymatic regulation investigations, and mechanistic evaluation of nicotinamide methylation pathways.
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- Independently Lab Tested
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- For Laboratory Research Use Only
3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C10H11IN2+ |
|---|---|
| Synonyms | 5-amino-1-methylquinolinium, SCHEMBL6403148 CHEMBL4116828, ZINC552049, STL196667 |
| Molar Mass | 159.21 g/mol |
| CAS Number | 42464-96-0 |
| PubChem CID | 950107 |
| Total Compound Content | 3,000 mg (50 mg per capsule) |
| Shelf Life | 36 months |
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
What enzyme does 5-Amino-1MQ inhibit?
5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT), a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide. Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology.
How does 5-Amino-1MQ differ from compounds such as NMN and NR in pathway research?
NMN and NR are commonly studied in relation to nicotinamide-associated metabolic pathways, whereas 5-Amino-1MQ acts through selective inhibition of NNMT. This distinct mechanism makes 5-Amino-1MQ a useful research tool for examining enzymatic regulation of nicotinamide turnover, methylation pathway dynamics, enzyme-inhibitor interactions, and regulatory processes associated with NNMT activity. Comparative investigations frequently utilize these compounds to explore different aspects of nicotinamide-related biochemical networks.
Why is 5-Amino-1MQ widely used in NNMT research?
5-Amino-1MQ possesses a well-characterized pharmacological profile and high selectivity for NNMT, making it a valuable reference compound for studies involving NNMT enzyme biology, methyltransferase pathway regulation, structure-activity relationships, and inhibitor-target interactions. Its established mechanism of action continues to support mechanistic investigations into nicotinamide methylation pathways and the broader role of NNMT within cellular regulatory networks.
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