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SR-9011 (5mg/capsule), 60 Capsules
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
SR-9011 is a synthetic small-molecule agonist of the nuclear receptors REV-ERBα (NR1D1) and REV-ERBβ (NR1D2), members of the nuclear receptor superfamily that function as ligand-dependent transcriptional repressors. Activation of REV-ERB receptors influences transcriptional regulatory networks through recruitment of corepressor complexes, including NCoR and HDAC3, resulting in suppression of target gene expression. Experimental investigations have examined SR-9011 in studies of circadian clock regulation, transcriptional control mechanisms, nuclear receptor signaling, and coordinated gene regulatory networks. Research applications include REV-ERB pharmacology, circadian rhythm signaling investigation, transcriptional regulation studies, nuclear receptor biology, and mechanistic evaluation of circadian-associated regulatory systems.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C23H31ClN4O3S |
|---|---|
| Synonyms | SR9011, REV-ERBα/β agonist |
| Molar Mass | 479.0 g/mol |
| CAS Number | 1379686-29-9 |
| PubChem CID | 57394021 |
| Total Compound Content | 300 mg (5 mg per capsule) |
| Shelf Life | 36 months |
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
How does SR-9011 affect REV-ERB-mediated transcriptional regulation?
SR-9011 is a dual agonist of REV-ERBα and REV-ERBβ, nuclear receptors that function as transcriptional repressors within gene regulatory networks. Activation of REV-ERB receptors promotes recruitment of corepressor complexes to response elements within target genes, resulting in suppression of transcriptional activity. This mechanism makes SR-9011 a valuable research tool for investigating transcriptional repression, receptor-cofactor interactions, and nuclear receptor-mediated gene regulation.
What makes SR-9011 useful for REV-ERB pharmacology research?
SR-9011 activates both REV-ERBα and REV-ERBβ, providing a single molecular tool for studying coordinated REV-ERB receptor signaling. Experimental investigations have utilized SR-9011 to examine receptor activation mechanisms, transcriptional control processes, circadian-associated regulatory pathways, and interactions between nuclear receptors and corepressor complexes. Its dual-receptor profile makes it particularly useful for comparative studies of REV-ERB-mediated signaling systems.
What are the primary research applications of SR-9011?
SR-9011 is widely used in studies of REV-ERB pharmacology, circadian-associated signaling networks, transcriptional regulation, and nuclear receptor biology. Research applications include investigation of receptor-mediated gene repression, response element regulation, cofactor recruitment mechanisms, and coordinated regulatory pathways controlled by REV-ERB receptors. These characteristics make SR-9011 a valuable tool for mechanistic studies of transcriptional control and nuclear receptor signaling systems.
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