Product Usage: This product is intended for research purposes only.
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HCG 5000 IU
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein produced by trophoblastic tissue during early embryogenesis. The α-subunit is structurally homologous to those of LH, FSH, and TSH; the unique β-subunit confers selective high-affinity binding to LHCGR. LHCGR engagement activates Gsα-coupled adenylyl cyclase, driving cAMP accumulation and PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3β-HSD. In preclinical cell-based models, hCG is used to interrogate Leydig cell responsiveness, CYP enzyme induction kinetics, and receptor desensitisation and internalisation dynamics. The prolonged plasma half-life of hCG relative to LH — attributable to the heavily sialylated β-subunit — makes it a preferred tool for studying sustained LHCGR stimulation versus pulsatile LH receptor engagement in experimental steroidogenesis models. Supplied as freeze-dried lyophilised preparation. Independently third-party HPLC-tested; COA available per batch.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
| Chemical Formula | C1105H1770N318O336S26 |
|---|---|
| Synonyms | Chorionic gonadotropin, Choriogonin, Gonabion |
| Molar Mass | 36,700 g/mol |
| CAS Number | 9002-61-3 |
| PubChem CID | 4369448 |
| Total Compound Content | 5,000 IU (1 vial) |
| Shelf Life | 36 months |
How does hCG differ from LH in receptor binding studies?
hCG and LH share the same receptor (LHCGR) but have significantly different half-lives. hCG's heavily sialylated β-subunit extends its plasma half-life to approximately 24–36 hours versus LH's 20–60 minutes. This makes hCG the preferred tool in preclinical models requiring sustained LHCGR stimulation rather than pulsatile receptor engagement.
What downstream signalling cascade does LHCGR activation initiate?
LHCGR is a Gsα-coupled GPCR. Ligand binding activates adenylyl cyclase, elevating intracellular cAMP and triggering PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3β-HSD. Parallel Gq/11-mediated IP3/DAG signalling has also been documented in some cell models.
What solvent is used to reconstitute HCG 5000 IU in laboratory protocols?
HCG 5000 IU lyophilisate is reconstituted with bacteriostatic water (BAC water) for laboratory use. The vial should be gently swirled — not vortexed — until fully dissolved. Reconstituted solution should be stored at 4°C and used within laboratory-established stability windows.
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