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Myostatin 1mg
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
Myostatin (GDF-8) is a TGF-β superfamily growth factor that functions as a key regulator of skeletal muscle mass through activation of the activin receptor pathway. Binding to ACVR2A/ACVR2B and subsequent recruitment of ALK4/ALK5 co-receptors initiates Smad2/3 signalling, resulting in transcriptional regulation of genes involved in muscle growth, differentiation, and protein turnover. Recombinant myostatin is widely used as a research tool for direct activation of the myostatin signalling pathway, providing a positive control for ACVR2B-mediated responses, Smad2/3 phosphorylation, and downstream transcriptional activity. Research applications include myostatin pathway characterization, activin receptor signalling studies, muscle biology research, pathway validation experiments, antagonist screening, and investigations of TGF-β superfamily signalling mechanisms.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C133H227N43O33 |
|---|---|
| Synonyms | 1621169-52-5, Myostatin inhibitory peptide 7, U8DGS69FVC Ala-Trp-Arg-Gln-Asn-Thr-Arg-Tyr-Ser-Arg-Ile-Glu-Ala-Ile-Lys-Ile-Gln-Ile-Leu-Ser-Lys-Leu-Arg-Leu-NH2, UNII-U8DGS69FVC, CHEMBL3410227, L-Alanyl-L-tryptophyl-L-arginyl-L-glutaminyl-L-asparaginyl-L-threonyl-L-arginyl-L-tyrosyl-L-seryl-L-arginyl-L-isoleucyl-L-alpha-glutamyl-L-alanyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-glutaminyl-L-isoleucyl-L-leucyl-L-seryl-L-lysyl-L-leucyl-L-arginyl-L-leucinamide, orb2563812 |
| Molar Mass | 2956.5 g/mol |
| CAS Number | 1621169-52-5 |
| PubChem CID | 118732224 |
| Total Compound Content | 1 mg per vial |
| Shelf Life | 24 months |
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
What is the primary research use of recombinant myostatin?
Recombinant myostatin is primarily used as a pathway activator in experimental systems. It provides direct activation of ACVR2A/ACVR2B-mediated Smad2/3 signalling, making it a standard positive control for myostatin pathway studies, receptor-binding experiments, signalling assays, and antagonist validation research. It is commonly paired with inhibitory compounds to evaluate pathway neutralisation and downstream signalling effects.
What concentrations are typically used in cell-based myostatin signalling studies?
Recombinant myostatin is active at low nanomolar and sub-nanomolar concentrations in many cell-based systems. Concentration-response experiments are commonly performed across a broad range to characterize receptor activation, Smad2/3 phosphorylation, transcriptional responses, and pathway sensitivity. Optimal concentrations depend on receptor expression levels and the specific experimental model being used.
What controls are important in myostatin pathway experiments?
Common controls include vehicle-treated samples for baseline measurements, pathway-positive controls to confirm Smad2/3 responsiveness, receptor or kinase inhibitors to verify pathway specificity, and myostatin-neutralising agents to confirm that observed responses are directly attributable to myostatin signalling. These controls help validate assay performance and ensure accurate interpretation of pathway activation results.
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