Product Usage: This product is intended for research purposes only.
All product information available on this website is for educational purposes only. Any form of bodily introduction into humans or animals is strictly prohibited by law. This product should only be handled by licensed and qualified professionals. It is not a drug, food, or cosmetic, and must not be misbranded, misused, or mislabeled as such.
GW-501516 (Cardarine), (10mg/capsule) 60 Capsules
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
GW-501516 (Cardarine) is a synthetic agonist of peroxisome proliferator-activated receptor delta (PPARδ), a ligand-activated nuclear receptor that regulates transcriptional activity through interaction with specific DNA response elements. High-affinity binding to PPARδ induces receptor conformational changes that promote co-regulator recruitment, transcriptional complex formation, and downstream gene expression modulation. Research applications include PPARδ pharmacology, nuclear receptor signaling, transcriptional regulation, ligand-receptor interaction studies, structure-activity relationship investigations, and comparative analyses of PPAR family agonists.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C21H18F3NO3S2 |
|---|---|
| Synonyms | Endurobol, GW501516, GW 501516, GW-501516, 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid |
| Molar Mass | 453.50 g/mol |
| CAS Number | 317318-70-0 |
| PubChem CID | 9803963 |
| Total Compound Content | 600 mg (10 mg per capsule) |
How does GW-501516's PPARδ selectivity differ from PPARα and PPARγ agonists?
GW-501516 exhibits high selectivity for PPARδ relative to other members of the peroxisome proliferator-activated receptor family. This selectivity enables investigation of PPARδ-dependent transcriptional activity without the confounding receptor interactions associated with PPARα or PPARγ agonists. As a result, GW-501516 is frequently utilized in studies examining receptor subtype specificity, co-regulator recruitment, and ligand-dependent nuclear receptor signaling.
What is the mechanism of action of GW-501516 at the PPARδ receptor?
GW-501516 binds PPARδ with high affinity, promoting receptor activation, heterodimerization with retinoid X receptor (RXR), and recruitment of transcriptional co-regulators. This process facilitates transcriptional complex assembly and modulation of downstream gene expression. These characteristics make GW-501516 a valuable tool for investigating PPARδ signaling mechanisms, transcriptional regulation, and ligand-receptor interactions.
Why is GW-501516 commonly used as a reference compound in PPARδ research?
A: GW-501516 possesses a well-characterized pharmacological profile, high receptor selectivity, and extensive documentation within the scientific literature. These properties have established it as a widely used reference compound for studies involving PPARδ pharmacology, nuclear receptor signaling, transcriptional pathway characterization, structure-activity relationships, and comparative investigations of PPAR family agonists.
-
SALE
-
SALE
-
-
-
-
SALE
-
SALE
-
SALE
