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S4 (Andarine), (25mg/capsule) 60 Capsules
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
S4 (Andarine, GTx-007) is a propanamide-class non-steroidal selective androgen receptor modulator (SARM) originally developed as a high-affinity androgen receptor (AR) ligand. It functions as a partial agonist at AR and has been characterized by its differential transcriptional activation profile across distinct androgen receptor signaling systems. Experimental investigations have demonstrated selective modulation of AR-mediated gene expression and receptor-cofactor interactions, distinguishing S4 from full androgen receptor agonists. Research applications include androgen receptor pharmacology, AR partial agonism studies, receptor-mediated transcriptional regulation, ligand-receptor interaction analysis, and structure-activity relationship investigations involving non-steroidal SARM scaffolds.
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- For Laboratory Research Use Only
3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C19H18F3N3O6 |
|---|---|
| Synonyms | Andarine, 401900-40-1, GTX-007, (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, GTX00 |
| Molar Mass | 441.4 g/mol |
| CAS Number | 401900-40-1 |
| PubChem CID | 9824562 |
| Total Compound Content | 1,500 mg (25 mg per capsule) |
| Shelf Life | 36 months |
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
What distinguishes S4 (Andarine) from other androgen receptor modulators?
S4 is a propanamide-class non-steroidal androgen receptor modulator characterized by partial agonist activity at the androgen receptor (AR). Unlike full AR agonists, S4 produces a distinct receptor-mediated transcriptional profile through differential co-activator recruitment and selective modulation of AR-dependent gene expression pathways. These characteristics make it a valuable research tool for investigating partial agonism, receptor pharmacology, and androgen receptor-mediated signaling mechanisms.
How does S4 compare to other non-steroidal androgen receptor modulators in research applications?
A: S4 belongs to a chemically distinct non-steroidal scaffold class and exhibits a well-characterized androgen receptor interaction profile. Comparative investigations frequently utilize S4 alongside other AR modulators to examine differences in receptor binding characteristics, co-regulator interactions, transcriptional responses, and structure-activity relationships. Its extensive characterization has established it as a widely referenced compound in androgen receptor pharmacology research.
Why is S4 useful for androgen receptor signaling studies?
S4 has been extensively investigated as a model compound for examining androgen receptor activation, receptor-cofactor interactions, and downstream transcriptional regulation. Experimental studies have explored its effects on AR-mediated signaling networks, ligand-receptor binding dynamics, and pathway-specific regulatory systems. These properties make S4 a useful research tool for studies of androgen receptor biology, transcriptional control mechanisms, and non-steroidal receptor modulator pharmacology.
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