Product Usage: This product is intended for research purposes only.
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RAD-140 (Testolone), (10mg/capsule) 60 Capsules
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
RAD-140 (Testolone) is a non-steroidal selective androgen receptor modulator (SARM) of the oxadiazole class, engineered for high-affinity, tissue-selective AR interaction. Radioligand competition assays confirm low-nanomolar Ki for AR, with functional selectivity characterised by differential co-regulator recruitment across tissue types in vitro. Research applications include AR structure–activity relationship studies, tissue-selective transcriptional activation profiling, and androgenic signalling pathway investigation.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C20H16ClN5O2 |
|---|---|
| Synonyms | 2-chloro-4-(((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile, RAD 140, Testolone |
| Molar Mass | 393.8 g/mol |
| CAS Number | 1182367-47-0 |
| PubChem CID | 44200882 |
| Total Compound Content | 600 mg (10 mg per capsule) |
| Shelf Life | 36 months |
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
How does RAD-140 differ from steroidal androgen receptor ligands in receptor pharmacology research?
RAD-140 is a non-steroidal androgen receptor modulator that binds AR with high affinity while inducing ligand-specific receptor conformations distinct from those produced by steroidal ligands. These conformational differences influence co-regulator recruitment, transcriptional activity, and downstream signaling behavior, making RAD-140 a valuable tool for investigating selective androgen receptor modulation and ligand-dependent receptor dynamics.
Q: What is the half-life of RAD-140 and how is it metabolized?
Pharmacokinetic investigations report an elimination half-life of approximately 60 hours. Metabolic characterization indicates oxidative biotransformation followed by conjugation pathways, with CYP-mediated metabolism contributing to compound clearance. Elimination profiles have been documented in experimental systems through both biliary and renal pathways.
Why is RAD-140 commonly used in androgen receptor signaling research?
RAD-140 combines high-affinity androgen receptor binding with a well-characterized pharmacological profile, making it useful for studies examining receptor activation mechanisms, co-regulator interactions, androgen response element (ARE) signaling, and structure-activity relationships. Its non-steroidal scaffold also makes it a valuable comparator in investigations of ligand-dependent androgen receptor behavior and selective receptor modulation.
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