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Hexarelin (Examorelin) 2mg
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
Hexarelin (Examorelin) is a synthetic hexapeptide growth hormone secretagogue and one of the most potent GHS-R1a agonists identified. Binding to GHS-R1a activates Gq/11-mediated phospholipase C signalling, resulting in IP3/DAG generation, intracellular calcium mobilization, and downstream secretagogue-associated signalling pathways. Unlike other members of the GHRP class, Hexarelin also interacts with CD36 (scavenger receptor class B), providing a secondary signalling mechanism independent of GHS-R1a activation. This dual receptor profile makes Hexarelin a valuable research tool for investigating GHS-R1a pharmacology, receptor-signalling dynamics, secretagogue potency relationships, CD36-mediated signalling pathways, and comparative peptide pharmacology. Experimental studies have also utilized Hexarelin in investigations of receptor cross-talk, intracellular signalling networks, and peptide-receptor selectivity. Supplied as lyophilized preparation (2 mg/vial).
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C47H58N12O6 |
|---|---|
| Synonyms | Examorelin, EP-23905, MF-6003, His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| Molar Mass | 887.05 g/mol |
| CAS Number | 140703-51-1 |
| PubChem CID | 6918297 |
| Total Compound Content | 2 mg per vial |
| Shelf Life | 36 months |
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
What is the CD36 receptor and why is Hexarelin's activity at this target significant?
CD36 (cluster of differentiation 36), also known as fatty acid translocase (FAT), is a class B scavenger receptor involved in lipid transport, fatty acid uptake, oxidized lipid recognition, and cellular metabolic signalling. Hexarelin is unique among GHS-R1a agonists in that it also interacts with CD36, providing a second pharmacological mechanism independent of growth hormone secretagogue receptor activation. This dual receptor profile makes Hexarelin a valuable research tool for investigating receptor-specific signalling pathways, metabolic regulation, lipid-sensing mechanisms, and the distinction between GHS-R1a-mediated and CD36-mediated biological effects.
How does Hexarelin compare to other GHS-R1a agonists in receptor potency studies?
Hexarelin is widely regarded as one of the most potent peptide agonists of GHS-R1a. Comparative pharmacology studies frequently utilize Hexarelin as a reference compound when evaluating receptor affinity, agonist efficacy, signalling kinetics, and downstream pathway activation among members of the GHRP class. Its high receptor potency and well-characterized signalling profile have established it as a standard tool in GHS-R1a research and comparative secretagogue pharmacology.
What research applications are uniquely associated with Hexarelin?
In addition to its role in GHS-R1a signalling research, Hexarelin is used to investigate CD36-associated pathways, receptor cross-talk mechanisms, lipid-regulated signalling networks, cellular stress-response pathways, and comparative receptor pharmacology. The presence of both GHS-R1a and CD36 activity allows researchers to design experiments that differentiate receptor-specific signalling events and examine the interaction between distinct peptide-responsive pathways within the same experimental system.
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