Other Names: Narbivolol, Nebivolol-d4, Nebivololum, 99200-09-6, 2,2′-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)
Total Amount of Active Ingredient: 300 mg
Concentration: 5 mg
Quantity: 60 capsules
Shelf Life: 36 months
What is Nebivolol?
It functions by altering how particular bodily components, including the heart, react to nerve impulses. The heart beats more slowly as a result, lowering blood pressure. The amount of blood and oxygen going to the heart is increased when blood pressure is reduced.
Benefits and Uses
- Prevents oxidative damage- Nebivolol’s dual -blockade and vasodilation qualities have made it a popular antihypertensive drug (via NO pathway). L-nebivolol and D-nebivolol are the two enantiomers that make up the racemic combination (1:1). Both isomers have a vasodilating action, however, L-nebivolol has a more pronounced vasodilating impact whereas the D-isomer essentially has no -blocking function. Nebivolol dramatically lowers blood pressure by vasodilation via the NO route in addition to its -adrenoreceptor blockage.
- Reduces kidney oxidative damage- Early hypertension can manifest as microalbuminuria and decreased glomerular filtration rate, which over time can progress to chronic renal failure. Patients with hypertension frequently experience renal impairment, such as thickening of the renal arteriolar walls, fibrinoid deposition, and proteinuria. Nephroangiosclerosis may result from persistent hypertension.
- Negates brain oxidative damage- One of the most significant risk factors for stroke is high blood pressure. In patients with hypertension, small vessel disease, such as silent lacunar infarcts, progressive deep white matter lesions, and micro bleeding, can cause ischemic and hemorrhagic stroke as well as vascular dementia.
Additional Information on Nebivolol
The substantial metabolization of nebivolol results in several active hydroxy-metabolites. Alicyclic and aromatic hydroxylation, N-dealkylation, and glucuronidation are the steps used to break down nebivolol. Additionally, the hydroxy-metabolites create glucuronides. The genetic oxidative polymorphism CYP2D6 dependent is a factor in the metabolic process of nebivolol through aromatic hydroxylation. Nebivolol’s typical oral bioavailability in people with quick or slow metabolism ranges from 12 to nearly 100 percent.