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HMG 75 IU
During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly same as standards.
Human Menopausal Gonadotropin (HMG) is a gonadotropin preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. These glycoprotein hormones interact with their respective receptors, follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/choriogonadotropin receptor (LHCGR), both of which belong to the G protein-coupled receptor (GPCR) superfamily. Activation of these receptors initiates Gsα-coupled signaling pathways, resulting in intracellular cAMP generation, protein kinase A (PKA) activation, and downstream signal transduction processes.
Experimental investigations have utilized HMG as a research tool for studying gonadotropin receptor pharmacology, receptor-ligand interactions, GPCR signaling mechanisms, receptor activation kinetics, and comparative analyses of FSHR and LHCGR-mediated pathways. Research applications include gonadotropin signaling studies, receptor characterization, signal transduction investigations, and mechanistic evaluation of glycoprotein hormone receptor biology.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
| Chemical Formula | N/A |
|---|---|
| Synonyms | 6,6-dimethylheptanal, Human Menopausal Gonadotrophin, Menotrophin, gonadotropin from human menopausal urine |
| Molar Mass | 142.24 g/mol |
| CAS Number | 61489-71-2 |
| PubChem CID | N/A |
| Total Compound Content | 75 IU per vial |
| Shelf Life | 36 months |
What is the significance of combined FSH and LH activity in HMG research?
HMG contains both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) bioactivity, enabling simultaneous investigation of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/choriogonadotropin receptor (LHCGR) signaling pathways. This combined receptor activity makes HMG a useful research tool for studying gonadotropin receptor pharmacology, receptor-ligand interactions, comparative GPCR signaling mechanisms, and the relationship between FSHR- and LHCGR-mediated signal transduction processes.
How does HMG differ from recombinant gonadotropin preparations?
HMG contains multiple glycoprotein hormone isoforms exhibiting varying degrees of glycosylation and sialylation, whereas recombinant preparations are generally characterized by more defined glycoform profiles. This molecular heterogeneity has made HMG valuable for investigations examining glycoprotein hormone structure-function relationships, receptor binding characteristics, glycoform-dependent signaling behavior, and the influence of glycosylation patterns on receptor activation kinetics.
What signaling pathways are activated by FSHR and LHCGR?
FSHR and LHCGR are members of the G protein-coupled receptor (GPCR) superfamily that primarily signal through Gsα-mediated activation of adenylyl cyclase, resulting in intracellular cAMP generation and protein kinase A (PKA) activation. These receptors are widely utilized in research examining GPCR signaling dynamics, receptor activation mechanisms, second-messenger systems, receptor-ligand interactions, and downstream signal transduction pathways associated with glycoprotein hormone receptor biology.
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