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Product Usage: This product is intended for research purposes only.

All product information available on this website is for educational purposes only. Any form of bodily introduction into humans or animals is strictly prohibited by law. This product should only be handled by licensed and qualified professionals. It is not a drug, food, or cosmetic, and must not be misbranded, misused, or mislabeled as such.

SS31 (Elamipretide)

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Peptides are stable at room temperature and can be stored in their original packaging for several days to weeks. For longer storage, keep them at 4 °C or colder, away from intense light. Do not shake peptides before or after reconstitution, refrigerate them, and handle with care.

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SS-31 is a mitochondria-targeted peptide that binds to cardiolipin in the inner mitochondrial membrane. It is widely studied for its effects on mitochondrial stability, oxidative stress, and cellular energy processes. Provided as a lyophilized powder, this compound is offered strictly for research use only.

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  • Independently Lab Tested
  • Research Grade Quality
  • For Laboratory Research Use Only
All SwissChems products are independently third-party tested at a USA-based HPLC-licensed laboratory prior to distribution. Certificates of Analysis (COA) are published on the Independent Test Results page and available at product level. If any independently conducted HPLC test returns a negative result, SwissChems will refund: (1) the cost of the HPLC test, and (2) the full order amount including shipping.
SS31 (Elamipretide)5mg | 10mg
Chemical Formula C32H49N9O5
Synonyms Elamipretide, MTP-131, Bendavia, Forzinity (trade name)
Molar Mass 639.80 g/mol
CAS Number 736992-21-5
PubChem CID 11764719
Total Compound Content 5 mg per vial
Shelf Life 24 months
SS-31 (Elamipretide; D-Arg-2',6'-Dmt-Lys-Phe-NH2) is a synthetic mitochondria-targeted tetrapeptide that selectively binds cardiolipin, a phospholipid unique to the inner mitochondrial membrane. Through cardiolipin interaction, SS-31 supports electron transport chain (ETC) supercomplex stability, preserves mitochondrial membrane architecture, and promotes efficient electron transfer. Experimental studies have demonstrated reduced mitochondrial reactive oxygen species (ROS) generation, improved ATP production, and preservation of mitochondrial membrane potential under conditions of mitochondrial stress. Research applications include cardiolipin biology, mitochondrial bioenergetics, ETC supercomplex investigation, oxidative stress pathways, ROS signalling, mitochondrial membrane dynamics, and mitochondrial dysfunction research. Supplied as lyophilised preparation. Independently third-party HPLC-tested; COA available per batch.

Every batch is independently lab tested for identity, purity and potency. View our lab testing program →

What is cardiolipin and why is it a key target for SS-31 research?

Cardiolipin is a phospholipid found exclusively within the inner mitochondrial membrane and plays a central role in maintaining mitochondrial structure and function. It supports electron transport chain (ETC) supercomplex organization, facilitates electron transfer efficiency, and contributes to mitochondrial membrane architecture. Because cardiolipin integrity is closely linked to mitochondrial performance, SS-31's selective interaction with cardiolipin makes it a valuable tool for studying mitochondrial bioenergetics, oxidative stress, and membrane dynamics.

How does SS-31 differ from BAM-15 in mitochondrial research?

SS-31 and BAM-15 target distinct aspects of mitochondrial biology. SS-31 acts through cardiolipin interaction, supporting ETC organization, mitochondrial membrane stability, and reduced oxidative stress. BAM-15 functions as a mitochondrial uncoupler, increasing respiration by dissipating the proton gradient across the inner mitochondrial membrane. As a result, SS-31 is commonly used to investigate cardiolipin biology, ETC efficiency, and ROS regulation, whereas BAM-15 is utilized for studies of mitochondrial uncoupling, energy expenditure, and metabolic adaptation.

What endpoints are commonly measured in SS-31 studies?

Common endpoints include mitochondrial ROS production, ATP generation, membrane potential maintenance, oxygen consumption rates, ETC supercomplex integrity, cardiolipin-dependent signalling, oxidative stress biomarkers, and overall mitochondrial bioenergetic performance. These measurements help characterize the effects of SS-31 on mitochondrial structure and function under experimental stress conditions.

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