Description
MK-677 (Ibutamoren) is a non-peptide ghrelin receptor agonist that mimics the action of endogenous ghrelin by binding to the growth hormone secretagogue receptor (GHS-R1a). This interaction influences various metabolic and enzymatic pathways involved in molecular signaling.
The compound exhibits high oral bioavailability and an extended half-life of approximately 24 hours, allowing for sustained receptor activation. It undergoes hepatic metabolism, primarily through cytochrome P450 enzyme pathways, before being processed via renal and biliary excretion.